He was recently featured on 60 Minutes, . Food/drugs to avoid while on fluvoxamine. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. . . Online Status. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. Steve put in $1MM of his own money and . Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Once the Phase 2 result came out, it should have been embraced by doctors. 36m "We found Fauci was the most highly compensated federal employee. are all super cheap, effective, and available without a prescription. Added to FLCCC protocols and Fareed-Tyson protocol among others. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. What happens when your prescription drug becomes the center of covid misinformation. The. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. It cant be more clear than this. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. There are 4 outpatient studies that have been done (2 at WashU (see. We could have saved a lot of lives. They were giving covid patients the antidepressant fluvoxamine as soon as possible after diagnosis, based on anecdotes about the drug limiting the runaway immune response that causes many severe symptoms. Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. The US government accused Janssen of improperly promoting the antipsychotic drug Risperdal to dementia patients despite the drug increasing deaths in the elderly. Ive used it personally at 50mg twice a day and experience no adverse events at all. Added to FLCCC protocols and Fareed-Tyson protocol among others. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. I learned this the hard way. 19 In addition, several . Medicine isnt about saving lives anymore. It doesnt get any better than this. The web price charge of skirsch.io . He has been a medical philanthropist for more than 20 years. Thats why they didnt even fund the fluvoxamine trial, he told me. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Last Checked: 03/02/2023. See this. Medicine isnt about saving lives anymore. Dosing. Twenty-four years ago, . One Silicon Valley entrepreneur thought he could beat the odds. I wanted to get the article out before my flight left. . The NIH never did a risk benefit analysis of this drug. I fully expected both organizations to do absolutely nothing. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: There were IRB rules that required the 65 patients to be listed in the diagrams and charts. He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. I've collected fluvoxamine evidence here for convenient access. saying that the per-protocol analysis was arbitrary and other excuses. Ive used it personally at 50mg twice a day and experience no adverse events at all. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Thats what creates some of these heroes.. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Share this post. Three of the four outpatient trials have been reported out: all were successful. In some cases, youd want to taper down the dosage. Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals . But not 150K. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Doctors have no excuse for not prescribing. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. . 33. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. - Quora, Heres presentation I gave at the re-open California Conference on January 9,2021: How to fix the problemHow to fix the problem Steve Kirsch Executive DirectorCOVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008Google Docs[https://docs.google.com/presentation/d/1-A4y78wv3tTPmVu57FOabY6j-MJbPwMGojKwZfaCkAs/. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. (Clayton Fox, Marty Makary, and Jeffrey Klausner). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. We are ignoring the advice of the KOL group and doing nothing. Some people report mild nausea while on the drug (stops when stop the drug). . So far, doctors have failed to share his sense of urgency. Waiting months for the phase 3 trial to complete is nuts. Discover special offers, top stories, So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. This document is a collection of evidence that highlights the glaring errors in our pandemic response. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? Now weve lost the high ground, Morris told me. Talking to Kirsch is an exhausting experience. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Zero. The medical community did nothing (with a few exceptions like Dr. Seftel). It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. Some countries dont have fluvoxamine so this is the alternative. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. Sage Hana. You can use fluoxetine as well (aka Prozac). Several other trials around the world are in the final stages, too. No more. Doing something is better than nothing. Fluvoxamine has at least a 30% hospitalization and death benefit. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. That is when the phase 2 results were published. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Silence from the medical community. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? Stopping the meds will return you to your normal self. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. My crime? In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Most doctors wont use it until NIH greenlights it, no matter what the science says. Mar. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. You will be wired for 24 hours if you dont heed my advice. Proven in clinical use all over the world. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. He started a covid-19 vaccine company. For decades, coders wrote critical systems in C and C++. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. All can merit a fluvoxamine prescription based on traditional diagnoses. This drug can save your life but you have to ask for it! Online Status. Quick Summary . Steve is a Silicon Valley entrepreneur and philanthropist who founded the COVID-19 Early Treatment Fund (CETF) at the beginning of the pandemic. 95% confidence effect size is 75% or more. More recently, hes adopted extremist positions on covid vaccines, which he alleges are toxic. He has claimed that one in 1,000 people who have received mRNA vaccines have died as a result, and even claimed the vaccines kill more people than they save at an FDA public forum, which was first reported by the Daily Beast. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. ). Fluvoxamine has a 40 year safety track record. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Most recent articles first. P-value was 10^-14 on that study (done by Dr. Its whether Merck can make a killing that matters. So you can address your OCD and if you get COVID, youll can up the dose. I only know of a few doctors who prescribe this off-label, all with 100% success rates. Most doctors wont use it until NIH greenlights it, no matter what the science says. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. Everyone says "we need more data" to show fluvoxamine works for COVID. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. I believe they made the right decision and we should be rushing to follow their advice. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. They knew in advance it was coming and on the day the paper was published they ignored it entirely. My website. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. No long haul symptoms if you start the drug ASAP after first symptoms. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. It has shown to be 100% protective of hospitalization in 2 clinical trials. Long haul. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. There were no studies reported out so far where fluvoxamine made things worse or neutral. If you start 5 days after symptoms, all bets are off. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Note that some of these articles are inaccurate. People who report not tolerating the drug are typically prescribed too high a dose. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. One is to reduce the threat of nuclear war. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Former Silicon Valley tech executive Steve Kirsch, a philanthropist and Substack author who created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs, including fluvoxamine, which reduces death from COVID by a factor of 12. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. I have all of these on hand and I load up on vitamin D3 every day. That way you can start immediately. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). The paramedics will think you are on drugs. They knew in advance it was coming and on the day the paper was published they ignored it entirely. The medical community doesnt care about saving lives. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. But Kirsch is also motivated by an unsatisfied competitive streak. Mouse Systems is not a household word, he told the journalist. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Im not going to make the same mistake again.. One of the drugs, Fluvoxamine, showed a 30 . If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Note that some of these articles are inaccurate. It never was. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. Some speaker, off camera, went on a . This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Saving the world has been a theme of Kirschs life for years. Some are views most scientists think are wrong. Some countries dont have fluvoxamine so this is the alternative. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: But even she was drained by Kirschs constant attempts to override the data. Here is the latest version. Still, in the moment, his question threw me, and I stuttered. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. Compulsive hand washing? You can use fluoxetine as well (aka Prozac). All the supporting observational studies were positive as well. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). I have all of these on hand and I load up on vitamin D3 every day. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. No long haul symptoms if you start the drug ASAP after first symptoms. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. Medium banned him for misinformation. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. The medical community doesnt care about saving lives. (The fund borrows its nonprofit status from the 501(c)(3) Rockefeller Philanthropy Advisors, which managed its money until it quit, according to the Daily Beast; neither organization is related to the Rockefeller Foundation, which supports Technology Review's reporting on covid.). Their willingness to lie did. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. But they dont want their names used. Over the summer, the conflict reached his most recent startup, M10. 47).. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. No more. Always be self aware when using fluvoxamine. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. I fully expected both organizations to do absolutely nothing. And FrameMaker is still a niche product. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. CETF Founder Steve Kirsch discusses why we can't wait for a COVID-19 vaccine, the importance of researching existing drugs now, and our work to raise funds for outpatient trials to identify effective . So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? It's hard to ignore this lecture in explaining why the drug is so effective. . Im sorry to sound so cynical. . I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. In a recent post, discussing claims Kirsch made during a three-minute comment at an FDA public forum, Morris wrote: In spite of many pages of writing and claims of over a dozen independent analyses verifying their results, their evidence falls far short of substantiating these dramatic conclusions, including a claim that vaccines have caused >250K excess deaths in the USA.. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine He's founded 7 companies, 2 with billion dollar valuations. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. It doesnt get much better than that. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. A few months ago, Kirsch suddenly stopped promoting hydroxychloroquineeven scrubbing it from the CETFs official list of trials it has funded. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says.